On October 5, 2025, the NFL matchup between the Las Vegas Raiders and the Indianapolis Colts is set to take place at Lucas Oil Stadium in Indianapolis, starting at 1:00 PM. Heading into the game, the Las Vegas Raiders are currently 4th in their division and 10th in the conference with a 1-3-0 record, which calculates to a .250 winning percentage. They’ve scored a total of 77 points and conceded 99, resulting in a point differential of -22. On the other side, the Indianapolis Colts boast a stronger season so far. They stand at the top of their division and 4th in the conference, holding a record of 3-1-0 and a .750 winning percentage. The Colts have scored 123 points while allowing 83, accumulating a net point difference of +40. Details on last week’s games for both teams are currently not available. Quarterback Gardner Minshew II will be starting for the Raiders, and Anthony Richardson will helm the Colts. Check out betConnecticutSports.com for more game updates and sports news. For bettors, understanding the odds is crucial. The Indianapolis Colts are favored with a point spread of -8.00, indicating expectations for a significant home victory. The Raiders face a challenging game with an away point spread set at 9.10. The total points (over/under) established for this encounter is 54.20, which suggests anticipation of a high-scoring game. Moneyline odds are -370 for the Colts, showing strong confidence in their victory, while the Raiders are underdogs at +296.